DEVELOPMENT OF COMPOSITION AND TECHNOLOGY OF CAPSULATED DRUG BASED ON AMBROSIA AND HONEY POWDER
РОЗРОБКА СКЛАДУ ТА ТЕХНОЛОГІЇ КАПСУЛЬОВАНОГО ЛІКАРСЬКОГО ПРЕПАРАТУ НА ОСНОВІ ПЕРГИ ТА МЕДУ ПОРОШКОПОДІБНОГО
| dc.creator | Kudryk, B. Т. | |
| dc.creator | Тykhonov, O. I. | |
| dc.creator | Shpychak, O. S. | |
| dc.date | 2016-10-28 | |
| dc.date.accessioned | 2020-02-26T12:37:42Z | |
| dc.date.available | 2020-02-26T12:37:42Z | |
| dc.identifier | https://ojs.tdmu.edu.ua/index.php/pharm-chas/article/view/6819 | |
| dc.identifier | 10.11603/2312-0967.2016.3.6819 | |
| dc.identifier.uri | https://repository.tdmu.edu.ua/handle/123456789/14999 | |
| dc.description | Announcement 1. Research of organoleptic and physico-chemical indicators of the quality of ambrosia and honey powder Introduction. One of the most important part of health is preservation of immunological protection concerning necessary level, which conditions actuality of creation of new effective immunostimulating means. Devices of natural origin play important role, which profitably differ from synthetic immunostimulators by means of biological affinity to tissues of body, which are more popular concerning effectiveness in the market of medicines.New standardized medical substances of produces of beekeeping are deserved of great attention – ambrosia and honey powder. For the first time they were offered for development of new domestic medicines at National Pharmaceutical University. According to it, actual is creation of scientific – practical approaches to development of composition and technology of capsulated medicine of immunostimulating action based on above substances, which determined solution of problem of profilactics and treatment of sick people containing immunopathologies.Methods of research. Research of ambrosia and substance of honey powder provided conduction of analysis of indicators of their quality in accordance with expertise and their certification. In the course of analysis it was revealed, that in accordance with technical conditions DSТU 7074: 2009, GОSТ 31776-2012 and ТU U 10.8-39834691-001: 2015 every single batch of research susbstances is submitted to verification concerning state of packing and marking, as well as concerning organoleptic and physico – chemical indicators.Gradually basic requirements of safety in case of production of ambrosia and honey powder and their pre - packing were determined, аs well as admitted levels of toxic elements, pesticides and radionuclides in ambrosia and toxic elements, pesticides and antibiotics in substance of honey powder are determined. Tests concerning microbiological purity of ambrosia and honey powder and verification of fitness of these methodics were conducted in accordance with requirements of State pharmacopeia of Ukraine (SPU).Results and discussion. According to results of conducted experiments, some differences in national and interstate requirements of indicators of quality of ambrosia were established. By the way, mass part of water in accordance with national standard must be within 5,0 to 8,0 %, in comparison with unlike from 18,0%, admitted in GОSТ 31776-2012. Мass part of flavonoid compounds in national standard must be 2,5 %, it means by 2 % more than normative indicators, determined in comparable GОSТ. Indicator of concentration of hydrogen iones (рН) concerning national requirements also has considerable differences and is within 3,5 to 5, when by interstate requirements norm of current indicator must be no more than 3,0, which causes the alteration of environment from acid to acescent, and reduction of acidity, in it’s turn can have considerable impact on reduction of persistence of ambrosia to fermentation and loss of it’s stability.Researches also testify that experimental samples of ambrosia and honey powder concerning results of conducted organoleptic, physico – chemical and microbiological researches completely comply to requirements which are appropriate to regulations, and data of substance can be used later as acting substances in composition of developed medicine.So, possibility of application of produces of beekeeping and their standardized substances as acting substances exists in order to develop apimedicines later. Especially acute problem of quality of current raw materials exists. It has to do with requirements concerning SPU and national standards (DSТU, ТU), control of quality and safety. Besides, organoleptic and physico - chemical indicators suggest also determination of extremely admitted remnants of pesticides, heavy metals, radionuclides, antibiotics and conduction of tests concerning microbiological purity.Conclusions. Research of study of organoleptic and physico – chemical indicators of quality of ambrosia and standardized substance of honey powder was conducted, above components are included to composition of developed capsules «Api-Immuno-Vit» of immunomodulatory action, contents of toxic elements, pesticides, radionuclides and antibiotics in experimental samples of acting substances were determined. In case of comparison of interstate and national requirements with quality of ambrosia, desparity in such as principally important indicators as : mass part of water, concentration of hydrogen iones, mass part of flavonoid compounds and crude protein were established.Experimentally it was proved, that mixture consisting of biologically active substances of ambrosia and honey powder containing determined auxiliary substances allows to receive granules for creation of capsulated «Api-Immuno-Vit» of immunomodulatory action. | en-US |
| dc.description | У статті наведено результати проведених експериментальних досліджень із вивчення органолептичних та фізико-хімічних показників якості перги та стандартизованої субстанції меду порошкоподібного, що входять до складу досліджуваного лікарського препарату «Апі-Імуно-Віт» імуномодулюючої дії, а також встановлено показники безпеки досліджуваних активних фармацевтичних інгредієнтів (АФі) відповідно до вимог національних та міждержавних стандартів та визначено вміст токсичних елементів, пестицидів, радіонуклідів і антибіотиків в експериментальних зразках. | uk-UA |
| dc.format | application/pdf | |
| dc.language | ukr | |
| dc.publisher | Тернопільський державний медичний університет імені І. Я. Горбачевського МОЗ України | uk-UA |
| dc.relation | https://ojs.tdmu.edu.ua/index.php/pharm-chas/article/view/6819/6220 | |
| dc.rights | Авторське право (c) 2016 Фармацевтичний часопис | uk-UA |
| dc.rights | https://creativecommons.org/licenses/by-nc-nd/4.0 | uk-UA |
| dc.source | Pharmaceutical Review; No. 3 (2016); 11-17 | en-US |
| dc.source | Фармацевтичний часопис; № 3 (2016); 11-17 | uk-UA |
| dc.source | 2414-9926 | |
| dc.source | 2312-0967 | |
| dc.source | 10.11603/2312-0967.2016.3 | |
| dc.subject | ambrosia | en-US |
| dc.subject | honey powder | en-US |
| dc.subject | physico-chemical properties | en-US |
| dc.subject | «Api-Immuno-Vit» capsules | en-US |
| dc.subject | immuno-modulatory action | en-US |
| dc.subject | перга | uk-UA |
| dc.subject | мед порошкоподібний | uk-UA |
| dc.subject | фізико-хімічні властивості | uk-UA |
| dc.subject | капсули «Апі-Імуно-Віт» | uk-UA |
| dc.subject | імуномодулююча дія | uk-UA |
| dc.title | DEVELOPMENT OF COMPOSITION AND TECHNOLOGY OF CAPSULATED DRUG BASED ON AMBROSIA AND HONEY POWDER | en-US |
| dc.title | РОЗРОБКА СКЛАДУ ТА ТЕХНОЛОГІЇ КАПСУЛЬОВАНОГО ЛІКАРСЬКОГО ПРЕПАРАТУ НА ОСНОВІ ПЕРГИ ТА МЕДУ ПОРОШКОПОДІБНОГО | uk-UA |
| dc.type | info:eu-repo/semantics/article | |
| dc.type | info:eu-repo/semantics/publishedVersion |
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