PROTEIN METABOLISM UNDER CONDITIONS OF TOXINS OF AMANITA PHALLOIDES

Abstract

The aim of this work is: • to present an overview of the knowledge on amanitins, including the latest advances that could allow the proposal of new innovative and effective therapeutics; • to provide a comprehensive review of the mechanisms of toxicity, some biochemical parameters and underlying pathobiochemical mechanisms associated with Amanita phalloides poisoning; • to performe a systematic review to investigate the effect of the most commonly used antidotes: N-acetylcysteine (NAC), benzylpenicillin (PEN), and silibinin (SIL) on patient outcomes with Amanita phalloides poisoning.